Our Vision

SleepHuB is a unique network of clinicians, scientists and engineers who work collaboratively to conceptualize and operationalize translational projects related to sleep. We seek to improve sleep health through the development of novel diagnostic and therapeutic technologies. We will facilitate and perform innovative interdisciplinary research that encompasses: the quantitative physiology of normal and abnormal sleep; the development & application of state-of- the-art predictive models and imaging methodologies for sleep apnea; for pediatric and adult sleep apnea and snoring.

We also aim to position USC as the leading research institution focusing on sleep health with significant technological and methodological contributions from bioengineering.

Developing Technologies to Improve Sleep Health


We bring together systems physiology, computational modeling, and imaging together to advance sleep health, diagnostics and therapeutics. Our efforts span several traditional disciplines (e.g. Engineering, Medicine, Surgery) which allows us to investigate the many complex questions in normal and abnormal sleep. Current projects range from the development of smart low-cost and non-intrusive methods for early detection of sleep disorders, to new forms of patient-specific therapy.

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Publications (Coming Soon!)

Research Portfolio

Sleep and the Heart Non-lethal cardiac arrhythmias are common during diagnostic polysomnography, particularly in patients with sleep disordered breathing in the context of other comorbid diseases such as chronic obstructive pulmonary disease. We aim to develop a deeper understanding and predictive models of the relationship between these events and development of life threatening arrhythmias such as atrial and ventricular tachycardias, heart block and atrial fibrillation. Read More.
Integrative Systems of Physiology of Sleep The spontaneous variabilities observed in measurements of respiration, heart rate, blood pressure and sleep-wake state reflect the dynamics of complex interactions that take place among the underlying physiological mechanisms. Our overall goal is to elucidate the nature of these dynamic changes through a combination of non-invasive monitoring, bioimaging, and computational modeling.Read More.
Pediatric Sleep-related Breathing Disorders This research area includes sleep apnea in adolescents suffering from obesity, sleep related breathing disorders in infancy, and obstructive sleep apnea in individuals with craniofacial differences. Read More.
Sleep Apnea Diagnostics and Therapeutics Obstructive sleep apnea (OSA) surgery outcomes vary widely, ranging from 5% to 65% for individual or combination procedures. To predict – and thereby to improve – outcomes, we are examining the role of drug-induced sleep endoscopy in surgical evaluation and treatment. We are also developing ways to evaluate and improve electrical stimulation of the hypoglossal nerve for treatment of OSA. Read More.
Dynamic Imaging during Sleep Anatomic and functional properties of the upper airway are important to maintain proper breathing during sleep, and are the source of some of the most common sleep problems.Read More.

Center Leadership Team

Michael Khoo

Michael C.K. Khoo, Ph.D.

Center Director

Biomedical Engineering

Krishna Nayak

Krishna Nayak, Ph.D.

Ming Hsieh Department of
Electrical Engineering

Sally D. Ward

Sally Davidson Ward, M.D.

Pediatric Pulmonology and Sleep Medicine
CHLA/Keck School of Medicine

Terese Hammond

Terese Hammond, M.D.

Pulmonary & Critical Care Medicine and Sleep Medicine
Keck School of Medicine

Eric Kezirian

Eric Kezirian, M.D., M.P.H.

Otolaryngology—Head & Neck Surgery, Keck School of Medicine

Tomas Konecny

Tomas Konecny, M.D.

Cardiovascular Medicine, Keck School of Medicine Tomas.Konecny@med.usc.edu