Non-lethal cardiac arrhythmias are common during diagnostic polysomnography, particularly in patients with sleep disordered breathing in the context of other comorbid diseases such as chronic obstructive pulmonary disease. We aim to develop a deeper understanding and predictive models of the relationship between these events and development of life threatening arrhythmias such as atrial and ventricular tachycardias, heart block and atrial fibrillation.
(Lead Investigators: Tomas Konecny and Terese Hammond)
Sleep-disordered breathing in hypertrophic cardiomyopathy: challenges and opportunities.
Konecny T, Somers VK. Chest. 2014 Jul;146(1):228-234. doi: 10.1378/chest.14-0084. Review. PMID: 25010966
Chronic obstructive pulmonary disease as a risk factor for ventricular arrhythmias independent of left ventricular function.
Konecny T, Somers KR, Park JY, John A, Orban M, Doshi R, Scanlon PD, Asirvatham SJ, Rihal CS, Brady PA. Heart Rhythm. 2017 Oct 3. pii: S1547-5271(17)31190-6. doi: 10.1016/j.hrthm.2017.09.042. [Epub ahead of print] PMID: 28986334
Model-Derived Markers of Autonomic Cardiovascular Dysfunction in Sleep-Disordered Breathing.
Khoo MCK, Chalacheva P. Sleep Med Clin. 2016 Dec;11(4):489-501. doi: 10.1016/j.jsmc.2016.07.003. Epub 2016 Oct 27. Review. PMID: 28118872